From 2004, it's Say Anything and their harrowing yet strangely uplifting "Alive With the Glory of Love."
This song, which I think is kind of a masterpiece, is also newly relevant, given the horrific scenes of children in cages we've been seeing for the last couple of days. That's all I'm gonna say about that at the moment. In any case, this is to my knowledge the only pop punk song whose subject is the love between a Jewish man and woman beset by the Nazis during WW II.
On a less somber note, I can only add that any song that steals the beat from The Supremes' "You Can't Hurry Love" is probably eternally relevant.
[h/t Dan Fridman]